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01 Ruben


For this project, we collaborated with Jansen Research and Development to find a novel reaction which gives easy access to 5-bromopyrimidines via the cyclization of 1,2-dibromoenones and amidines. These bromopyridines are not accessible via conventional electrophylic bromination of the pyrimidine core and hence a novel method was devised. The article's complimentary data includes several examples of compounds that were synthesized at Mercachem, using this method.

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