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Update COVID-19:

The COVID-19 situation is currently impacting most of the globe, including Asia, Europe and North America. At all MercachemSyncom sites, we follow the recommendations of the local competent authorities as they are released. We have established a series of contingency measures aimed at reducing risks for our employees, their families and the MercachemSyncom Operations. These measures are proactively being reassessed at regular intervals and adapted as deemed appropriate.

The MercachemSyncom team is united and determined to face the situation with the energy, strength and passion that constitute one of our hallmarks.


 

01 Ruben

 

For this project, we collaborated with Jansen Research and Development to find a novel reaction which gives easy access to 5-bromopyrimidines via the cyclization of 1,2-dibromoenones and amidines. These bromopyridines are not accessible via conventional electrophylic bromination of the pyrimidine core and hence a novel method was devised. The article's complimentary data includes several examples of compounds that were synthesized at Mercachem, using this method.

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